abstract：:The NRG1 growth factor and ERBB4 receptor have been identified as leading schizophrenia risk genes. Although NRG1 and ERBB4 have been shown to modulate neuronal functions involved in schizophrenia, including both GABAergic and glutamatergic synapses, the exact molecular mechanisms remain poorly understood. Here we inv...

journal_title：Neuroscience research

authors： Allison JG,Das PM,Ma J,Inglis FM,Jones FE

更新日期：2011-06-01 00:00:00

abstract：:Some evidence suggests that sleep deprivation might impair synaptic plasticity and produce oxidative stress in the hippocampus. However it is not clear whether impairment of long-term potentiation depends on the oxidative stress evoked by sleep deprivation protocol. In this study we aimed to investigate the effects of...

journal_title：Neuroscience research

authors： Süer C,Dolu N,Artis AS,Sahin L,Yilmaz A,Cetin A

更新日期：2011-05-01 00:00:00

abstract：:We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...

journal_title：Neuroscience research

authors： Otsu M,Sai T,Nakayama T,Murakami K,Inoue N

更新日期：2011-04-01 00:00:00

abstract：:The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...

journal_title：Neuroscience research

authors： Alvarez-Erviti L,Couch Y,Richardson J,Cooper JM,Wood MJ

更新日期：2011-04-01 00:00:00

abstract：:Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal lev...

journal_title：Neuroscience research

authors： Koike T,Kan S,Misaki M,Miyauchi S

更新日期：2011-04-01 00:00:00

abstract：:The contribution of nociceptive Aδ-fibres and C-fibres of the central pad of the foot to nociceptive spinal flexor reflex pathways (FRA-type) and to nociceptive excitatory reflex pathways to foot extensors (non-FRA type) was investigated in high spinal cats. Persisting effects after complete blocking of A-fibres by te...

journal_title：Neuroscience research

authors： Schomburg ED,Dibaj P,Steffens H

更新日期：2011-03-01 00:00:00

abstract：:l-Serine is required for the synthesis of glycine and d-serine, both of which are NMDA receptor co-agonists. Although roles for d-serine and glycine have been suggested in schizophrenia, little is known about the role of the l-serine synthesizing cascade in schizophrenia or related psychiatric conditions. Here we repo...

journal_title：Neuroscience research

authors： Ozeki Y,Pickard BS,Kano S,Malloy MP,Zeledon M,Sun DQ,Fujii K,Wakui K,Shirayama Y,Fukushima Y,Kunugi H,Hashimoto K,Muir WJ,Blackwood DH,Sawa A

更新日期：2011-02-01 00:00:00

abstract：:Hippocampal neurogenesis is influenced by many factors. In this study, we examined the effect of tactile stimulation (tickling), which induced positive emotion, on neurogenesis in the dentate gyrus (DG) of the hippocampus. Four week-old rats were tickled for 5 min/day on 5 consecutive days and received 5-bromo-2'-deox...

journal_title：Neuroscience research

authors： Yamamuro T,Senzaki K,Iwamoto S,Nakagawa Y,Hayashi T,Hori M,Sakamoto S,Murakami K,Shiga T,Urayama O

更新日期：2010-12-01 00:00:00

abstract：:This paper describes for the first time the phenomenon of spatio-temporal mapping of interchannel temporal coincidences of rapid transition processes (RTPs) in multiple EEG frequencies. It is suggested that RTPs in multiple EEG frequencies found in different EEG channels could reflect the process of switching between ...

journal_title：Neuroscience research

authors： Fingelkurts AA,Fingelkurts AA

更新日期：2010-11-01 00:00:00

abstract：:Zinc is one of trace elements that play essential roles in several cell functions, and is unquestionably important to the normal health and function of the central nervous system. Growing evidence suggests that Zn(2+) can become a pathogenic agent in certain neurological disease states, such as ischemia, seizures, and...

journal_title：Neuroscience research

authors： Tian Y,Yang Z,Zhang T

更新日期：2010-11-01 00:00:00

abstract：:The human cerebral neocortex is divided into six layers consisting of specific neuronal cell types and connections. To determine the distribution of cortical neurons during early development, we examined the expressions of layer-specific markers in human midterm fetal brains. Layer V marker ZNF312 is expressed in most...

journal_title：Neuroscience research

authors： Zhu H,Yang Y,Gao J,Tao H,Qu C,Qu J,Chen J

更新日期：2010-09-01 00:00:00

abstract：:Spinal cord injury (SCI) is a serious condition often affecting young and healthy individuals around the world. Electro-acupuncture (EA) has been proven to contribute towards neurologic and functional recoveries in SCI, but the underlying mechanism remains largely unknown especially regarding neural specific proteins ...

journal_title：Neuroscience research

authors： Li WJ,Pan SQ,Zeng YS,Su BG,Li SM,Ding Y,Li Y,Ruan JW

更新日期：2010-08-01 00:00:00

abstract：:Trans-2,4-dimethoxystibene (S(3)) is a synthetic stilbene. In this study, S(3) was investigated in terms of its neuroprotective effect against the toxicity induced by beta-amyloid(25-35) (Abeta(25-35)) both in vitro and in vivo. Protection by S(3) was studied at the in vivo level using a model of intracerebroventricul...

journal_title：Neuroscience research

authors： Ruan CJ,Zhang L,Chen DH,Li Z,Du GH,Sun L

更新日期：2010-07-01 00:00:00

abstract：:DJ-1 is a multifunctional protein linked to recessively inherited Parkinson's disease (PD) due to loss of function mutations. Among its activities is anti-oxidant property leading to cytoprotection under oxidative stress conditions. A key effector of oxidant-induced cell death is the MAP3 kinase apoptosis signal-regul...

journal_title：Neuroscience research

authors： Im JY,Lee KW,Junn E,Mouradian MM

更新日期：2010-07-01 00:00:00

abstract：:It is still incompletely known how NMDA receptors (NMDA-R) regulate bidirectional synaptic plasticity. We examined this issue by an experimental protocol in which paired pulse stimulation (PPS) with 50ms interstimulus interval and basal frequency of 0.1Hz was applied to CA1 area of rat hippocampal slices during low Mg...

journal_title：Neuroscience research

authors： Huang FS,Abbas AK,Li R,Afanasenkau D,Wigström H

更新日期：2010-06-01 00:00:00

abstract：:Although the rat has been the predominant rodent used to investigate the pathophysiology and treatment of experimental spinal cord injury (SCI), the increasing availability of transgenic animals has led to greater use of mouse models. However, behavioral assessment after SCI in mice has been less extensively investiga...

journal_title：Neuroscience research

authors： Pajoohesh-Ganji A,Byrnes KR,Fatemi G,Faden AI

更新日期：2010-06-01 00:00:00

abstract：:To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (I(T)), we examined the Zn(2+)-induced alterations of gating properties of I(T) of a rat thalamic relay neuron and of alpha1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effec...

journal_title：Neuroscience research

authors： Noh J,Kim MK,Chung JM

更新日期：2010-04-01 00:00:00

abstract：:The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...

journal_title：Neuroscience research

authors： Oki K,Kaneko N,Kanki H,Imai T,Suzuki N,Sawamoto K,Okano H

更新日期：2010-04-01 00:00:00

abstract：:The present study focused on the early stages of acute glutamate (L-Glu)-induced neurotoxic mechanisms, both biochemical, e.g. intracellular reactive oxygen species (ROS) and associated parameters as well as gene expression of cell survival/death pathways, i.e. Bcl-2 and caspases. Stereotactic intracortical injections...

journal_title：Neuroscience research

authors： Kumar A,Singh RL,Babu GN

更新日期：2010-03-01 00:00:00

abstract：:Disturbed circadian rhythmicity is associated with human diseases such as sleep and mood disorders. However, study of human endogenous circadian rhythm is laborious and time-consuming, which hampers the elucidation of diseases. It has been reported that peripheral tissues exhibit circadian rhythmicity as the suprachia...

journal_title：Neuroscience research

authors： Ebisawa T,Numazawa K,Shimada H,Izutsu H,Sasaki T,Kato N,Tokunaga K,Mori A,Honma K,Honma S,Shibata S

更新日期：2010-02-01 00:00:00

abstract：:A brain-machine interface (BMI) uses neurophysiological signals from the brain to control external devices, such as robot arms or computer cursors. Combining augmented reality with a BMI, we show that the user's brain signals successfully controlled an agent robot and operated devices in the robot's environment. The u...

journal_title：Neuroscience research

authors： Kansaku K,Hata N,Takano K

更新日期：2010-02-01 00:00:00

abstract：:Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N((omega))-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected...

journal_title：Neuroscience research

authors： O'Hare E,Elliott JJ,Hobson P,O'Mara SM,Spanswick D,Kim EM

更新日期：2010-02-01 00:00:00

abstract：:Intracellular pH (pH(i)) plays an important role in the regulation of central nervous system function. In the present study, we examined whether hydrogen sulfide (H(2)S), a recently recognized neuromodulator, regulates pH(i) in rat primary cultured glia cells. pH(i) was measured with a fluorescent sensitive dye, BCECF...

journal_title：Neuroscience research

authors： Lu M,Choo CH,Hu LF,Tan BH,Hu G,Bian JS

更新日期：2010-01-01 00:00:00

abstract：:Trauma to the spinal cord initiates a series of cellular and biochemical processes that damage both neurons and glia. TGF-beta and its receptors are expressed around the injury site following a spinal cord injury. Here, we report that the intrathecal administration of a neutralizing antibody to TGF-beta1 in rats with ...

journal_title：Neuroscience research

authors： Kohta M,Kohmura E,Yamashita T

更新日期：2009-12-01 00:00:00

abstract：:Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old...

journal_title：Neuroscience research

authors： Krasnova IN,Hodges AB,Ladenheim B,Rhoades R,Phillip CG,Cesena A,Ivanova E,Hohmann CF,Cadet JL

更新日期：2009-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive degeneration of motoneurons. We have demonstrated that hepatocyte growth factor (HGF) attenuates loss of both spinal and brainstem motoneurons of ALS model mice expressing mutated human SOD1(G93A) (G93A). This study was designed to ass...

journal_title：Neuroscience research

authors： Kadoyama K,Funakoshi H,Ohya-Shimada W,Nakamura T,Matsumoto K,Matsuyama S,Nakamura T

更新日期：2009-10-01 00:00:00

abstract：UNLABELLED:Angiotensin II receptors (Ang II), classified into AT1 and AT2 subtypes, are located in different regions of the central nervous system, including the cardiovascular control centers in the medulla oblongata. We previously reported the role of Ang II AT1 receptors within the medulla on cardiovascular response...

journal_title：Neuroscience research

authors： Tedesco A,Ally A

更新日期：2009-08-01 00:00:00

abstract：:To gain insight into the basic neurobiological processes regulated by lithium--an effective drug for bipolar disorder--we used Affymetrix Genome Arrays to examine lithium-induced changes in genome-wide gene expression profiles of head mRNA from the genetic model organism Drosophila melanogaster. First, to identify the...

journal_title：Neuroscience research

authors： Kasuya J,Kaas G,Kitamoto T

更新日期：2009-08-01 00:00:00

abstract：:We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the ...

journal_title：Neuroscience research

authors： Ye R,Li N,Han J,Kong X,Cao R,Rao Z,Zhao G

更新日期：2009-07-01 00:00:00

abstract：:T-type Ca2+ channel-dependent long-term potentiation (LTP) occurs predominantly during the critical period of ocular dominance plasticity in rat and cat visual cortex. Noradrenaline and serotonin are known to facilitate ocular dominance plasticity. In this study using rat visual cortical slices, we tested whether this...

journal_title：Neuroscience research

authors： Inaba M,Maruyama T,Yoshimura Y,Hosoi H,Komatsu Y

更新日期：2009-06-01 00:00:00

abstract：:During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in...

journal_title：Neuroscience research

authors： Watanabe H,Murakami F

更新日期：2009-05-01 00:00:00

abstract：:In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...

journal_title：Neuroscience research

authors： Yoshida M,Satoh T,Nakamura KC,Kaneko T,Hata Y

更新日期：2009-05-01 00:00:00

abstract：:RNA editing provides a post-transcriptional mechanism to increase structural heterogeneity of gene products. Recently, the alpha3 subunit of the GABAA receptors has been shown to undergo RNA editing. As a result, a highly conserved isoleucine residue in the third transmembrane domain is replaced with a methionine. To ...

journal_title：Neuroscience research

authors： Nimmich ML,Heidelberg LS,Fisher JL

更新日期：2009-04-01 00:00:00

abstract：:The role of cholinergic basal forebrain inputs to cerebral cortex in regulating regional nerve growth factor (NGF) secretion was examined in adult (4-6 months) and aged (29-31 months) rats. Halothane-anesthetized rats received unilateral electrical stimulation of the nucleus basalis of Meynert (NBM). NGF levels were m...

journal_title：Neuroscience research

authors： Hotta H,Kagitani F,Kondo M,Uchida S

更新日期：2009-02-01 00:00:00

abstract：:We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...

journal_title：Neuroscience research

authors： Nishitani S,Miyamura T,Tagawa M,Sumi M,Takase R,Doi H,Moriuchi H,Shinohara K

更新日期：2009-01-01 00:00:00

abstract：:The chemical properties of probes that improve amyloid detection by non-invasive (19)F magnetic resonance imaging (MRI) are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp (19)F nuclear magnetic resonance (NMR) signals in an assay buffer. H...

journal_title：Neuroscience research

authors： Amatsubo T,Morikawa S,Inubushi T,Urushitani M,Taguchi H,Shirai N,Hirao K,Kato M,Morino K,Kimura H,Nakano I,Yoshida C,Okada T,Sano M,Tooyama I

更新日期：2009-01-01 00:00:00

abstract：:The periaqueductal gray (PAG)-nucleus retroambiguus (NRA) pathway has been known to be involved in the control of vocalization and sexual behavior. To know how the amygdaloid complex influences the PAG-NRA pathway, here we first examined the synaptic organization between the central amygdaloid nucleus (CeA) fibers and...

journal_title：Neuroscience research

authors： Oka T,Tsumori T,Yokota S,Yasui Y

更新日期：2008-12-01 00:00:00

abstract：:In rat models of Parkinson's disease, injections of 6-hydroxydopamine (6-OHDA) into different areas of the basal ganglia result in dopaminergic neurodegeneration in the substantia nigra. The extent and time course of the dopaminergic lesions varies between the models. While the effects on neurons have been extensively...

journal_title：Neuroscience research

authors： Henning J,Strauss U,Wree A,Gimsa J,Rolfs A,Benecke R,Gimsa U

更新日期：2008-12-01 00:00:00

abstract：:Prepulse inhibition (PPI) and habituation of the acoustic startle reflex (ASR) are considered to be candidate endophenotypes of schizophrenia. However, to our knowledge, only one group has investigated these startle measures in Asian patients with schizophrenia. In the present study, we evaluated these startle measure...

journal_title：Neuroscience research

authors： Takahashi H,Iwase M,Ishii R,Ohi K,Fukumoto M,Azechi M,Ikezawa K,Kurimoto R,Canuet L,Nakahachi T,Iike N,Tagami S,Morihara T,Okochi M,Tanaka T,Kazui H,Yoshida T,Tanimukai H,Yasuda Y,Kudo T,Hashimoto R,Takeda M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...

journal_title：Neuroscience research

authors： Park YM,Che HJ,Im CH,Jung HT,Bae SM,Lee SH

更新日期：2008-10-01 00:00:00